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We have presented a range of papers which we hope you will find useful to download.
Effect of Lantharenol on apparent phosphorus absorption from a conventional feline maintenance diet and a renal diet for cats
B. Schmidt, U. Spiecker-Hauser, and J. Gropp,
Society of Nutritional Physiology 2008
Summary
Two P balance studies were performed in healthy adult purpose-bred European shorthair cats to compares Lantharenol efficacy in a conventional feline feedstuff rich in P with that in a P-restricted renal diet. The study design involved a one-week acclimation phase, a three week feeding period, and a subsequent ten days quantitative sampling of urine and faeces, with Lantharenol mixed daily into the feedstuffs to final concentrations of 0 (control) or 7.5 g kg-1 complete feed. Evaluation of P intake, faecal and urinary P excretion as well as apparent P digestibility indicated that Lantharenol significantly reduced apparent P digestibility in both the P-restricted and the P-unrestricted feedstuffs tested, lowering the burden of kidneys to excrete P. Due to the lower absolute P intake with the renal diet, the relative efficacy of Lantharenol in this P-restricted diet was higher than that in the normal diet. Click on the title below to download the full report.
Effect of Lantharenol on apparent phosphorus absorption from a conventional feline maintenance diet and a renal diet for cats.
Efficacy and safey of Lantharenol on phosphorus metabolism in cats with chronic kidney disease
B. Schmidt, U. Spiecker-Hauser, M. Murphy
American College of Veterinary Internal Medicine Forum 2008
Summary
This study assessed the efficacy and tolerance of this agent in cats with CKD induced by subtotal nephrectomy. The 10 azotaemic but normophosphataemic laboratory cats were fed a phosphorus rich diet supplemented with Lantharenol at 0-0.3-1.0-3.0-0 g/kg feed original substance for two weeks. Results demonstrated a dose-dependant reduction in phosphorus digestibility with no adverse effects on clinical status or palatability of the feed. In contrast to studies in healthy cats, these CKD cats showed an increased renal P excretion in response to Lantharenol®, indicating possible washout of intracellular P stores. There was no evidence of hypophosphataemia in CKD cats even after complete extinction of P digestibility for two weeks. Click on the title below to download the full report.
Efficacy and safety of Lantharenol on phosphorus metabolism in cats with chronic kidney disease.
BAY 78-1887, a novel Lanthanum based phosphate binder, decreases intestinal phosphorus absorption in cats
B. Schmidt, P. Delport, U. Spiecker-Hauser
European Academy of Veterinary Toxicology & Pharmacology 2006
Summary
This study in 32 healthy cats evaluated the effect of Bay 78-1887 (Lantharenol) administered at varying concentrations with a commercially available feline feed rich in phosphorus. Quantitative evaluation of fecal and urine P excretion, as well as apparent P digestibility in the feed and serum phosphorus levels indicated that there was a significant decrease in P digestibility, a decrease in urine P excretion and an increase in fecal P excretion associated with addition of the test compound. Additionally, there were no signs of intolerance or changes in phosphorus balance throughout the study. The results demonstrated that Bay 78-1887 (Lantharenol) safely and dose-dependantly reduces intestinal phosphorus absorbption in cats in the range of 1.6 to 16 g/kg dry feed, with maintenance of palatability. Click on the title below to download the full report.
BAY 78-1887, a novel Lantharenol-based phosphate binder, decreases intestinal phosphorus absorption in cats.
The use of Renalzin, a new intestinal phosphate binder, in feline chronic renal failure
B. Schmidt, K. Adler, K. Hellmann
Vetoalp Conference 2008
Summary
In a short-term clinical study, client-owned cats with decreased urine specific gravity and elevated serum creatinine and urea levels were allocated at random either to a control group fed a renal diet or to a group fed a normal diet plus Renalzin (400-600 mg of Lantharenol per day), for a two-month period. Evaluation of serum phosphate levels, clinical status and behavioural scores reported by owners indicated to an improvement in the Renalzin group. Feed intake remained stable or even improved in approximately 85% of the cats receiving the Renalzin supplement, compared to approximately 65% of the animals in the group receiving the prescription diet food. Click on the title below to download the full report.
Proceedings of the Vetoalp 2008 Conference, March 2008, Chamonix, France, p69.
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